Blood Markers of Brain Damage Higher in COVID-19 Patients than Alzheimer’s Patients in the Short-term, Study Finds

Blood Markers of Brain Damage News

Brain News – A new study found that in comparison to non-COVID-19 patients diagnosed with Alzheimer’s disease, patients hospitalized with COVID-19 had higher levels over the short term of blood proteins associated with neurological damage.

Researchers at NYU Grossman School of Medicine, compared COVID patients with those suffering from Alzheimer’s disease to determine whether COVID patients are at increased risk of Alzheimer’s disease or they could recover in the future. The study conducted in March–May 2020, identified seven blood markers of neurodegeneration: ubiquitin carboxy-terminal hydrolase L1 (UCHL1), total tau, ptau181, neurofilament light chain (NFL), glial fibrillary acidic protein (GFAP), Amyloid Beta 40 and 42, and toxic metabolic encephalopathy (TME).

The study divided the 251-COVID patient group into four categories comprising people with or without previous symptoms of cognitive unease, the discharged patients, and the dead patients. The comparison group of 161 control patients with Alzheimer’s disease belonged to the NYU Alzheimer’s Disease Research Center (ADRC) Clinical Core cohort. The blood markers in the COVID patient group were measured in blood serum, while those in the Alzheimer’s study were measured in plasma.

The findings—published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association—revealed that COVID patients had as high, even higher levels of blood markers of brain injury than those with Alzheimer’s disease. The first six markers were examined to compare levels in both groups, but the main measure of neurological damage in COVID patients was TME that was caused by toxins generated with sepsis, uremia, and hypoxia and resulted in symptoms from confusion to coma.

Specifically, the average percentage increase in levels of the seven markers for hospitalized patients with TME compared to those without neurological symptoms was 60.5 percent. For the same markers within the COVID-19 group, the average percentage increase when comparing those successfully discharged home from the hospital to those who died in the hospital was 124 percent.

Lead researcher, Thomas M. Wisniewski, MD, said, “Traumatic brain injury, which is also associated with increases in these biomarkers, does not mean that a patient will develop Alzheimer’s or related dementia later on, but does increase the risk of it. Whether that kind of relationship exists in those who survive severe COVID-19 is a question we urgently need to answer with on-going monitoring of these patients.”

To Know More You Refer To:

Frontera, J. A., Boutajangout, A., Masurkar, A. V., Betensky, R. A., Ge, Y., Vedvyas, A., Debure, L., Moreira, A., Lewis, A., Huang, J., Thawani, S., Balcer, L., Galetta, S., & Wisniewski, T. (2022). Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer’s dementia. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 10.1002/alz.12556. Advance online publication. https://doi.org/10.1002/alz.12556

Up Next

Can Talking To Strangers Help With Depression?

Can Talking To Strangers Ease Depression

Mental Health News

A group of researchers at the University of Sussex explored how talking to strangers can reduce depression. The study is published in the Journal of Experimental Social Psychology.

The Study

The researchers recruited participants on a weekly basis. The latter played a scavenger hunt game using a mobile app called GooseChase. They then had to talk to a stranger or simply observe the stranger.

After the experiment, they completed “General” and “Daily” surveys. They also answered pre-conversation and post-conversation questionnaires that assesse


READ FULL ARTICLE ⇲
Up Next

Partying With A Purpose: Are There Mental Health Benefits Of Celebrations?

What Are The Mental Health Benefits Of Celebrations

A recent study explored the health benefits of celebrations.

Experts have linked celebrations to reduced risks of mental health conditions.

Why Are Healthy Celebrations Beneficial?

Social celebrations are joyous occasions that essentially include eating, drinking, and gathering together. A recent study conducted by Indiana University revealed that such celebrations are beneficial for health, mental and physical. Its benefits include:

Perceived social support in c

READ FULL ARTICLE ⇲
Up Next

False Memories: Why Do Psychopaths Forget Negative Events?

False Memories

Psychology News

A team of researchers at the University of Bari, Italy, explored the link between psychopathy and the creation of false memories. The study is published in the British Journal of Psychology.

The Study

The researchers asked 120 participants, aged 18–65 years, to complete the Psychopathic Personality Inventory. They assessed the participants’ self-centered impulsivity, fearless dominance, and cold-heartedness.

The latter


READ FULL ARTICLE ⇲
Up Next

Parents’ Political Ideology Impacts How Their Children Punish Others: Study

Parents’ Political Ideology Impacts

Psychology News

A team of researchers at New York University explored how parents’ political ideology dictates their children’s punishment for others. The study is published in the journal Psychological Science.

The Study

The researchers examined 269 children, aged 3−8 years, and their parents from across the United States. They conducted a series of experiments and surveys.

The children were subject to conditions in which they would demonstrate the need to meet out punishment to others within and outside a social group. On the other hand, the parents completed a qu


READ FULL ARTICLE ⇲
Up Next

Research Reveals How Stress Affects Romantic Relationships

How Stress Affects Romantic Relationships

Mental Health News

A team of researchers at the University of Texas, Austin, explored how stress affects romantic relationships. The study is published in the journal Social Psychological and Personality Science.

The Study

The researchers surveyed a daily diary study of 79 newlywed couples. They assessed factors like stressful life events, partner’s negative and positive behaviors, partner perception, etc.

The Findings

The results revealed that


READ FULL ARTICLE ⇲
Billy Milligan: The Man With “24” Faces The Boy Who Stayed Awake For 11 Days Straight How Netflix’s “Wednesday” Explores Adolescent Stress And Therapy What Harry Potter Teaches Us About Mental Health? Nocturnal Panic Attacks: What are they & how to recover 10 Best Healthy Foods To Beat The Holiday Blues What Are The Struggles During Holidays & 5 Ways To Prevent It Holiday Depression: 13 Tips To Beat Holiday Blues I am feeling so “behind” in life 7 Frustrating Things About Living With BPD Are You An Impulse Shopper? 9 Tips To Stop Impulse Buying The Healing Power Of Music Therapy