Leaky Blood-Brain Barrier May Increase The Risk Of Schizophrenia, Researchers Say

Brain News: Blood-brain barrier protects the central nervous system against diseases and dangerous inflammation — at least when all is functioning normally. In a new study researchers have hypothesized that if this barrier is compromised, it could cause inflammation in the brain, which may, in turn, trigger schizophrenia.

Researchers at the University of Pennsylvania’s School of Veterinary Medicine in Philadelphia aimed to investigate the relationship between immunity and leaky blood-brain barrier and schizophrenia. They used cells isolated from healthy participants and from participants with a rare genetic disorder (known as DiGeorge syndrome or 22qDS) that increases the risk of schizophrenia.

Results showed that the blood-brain barriers derived from cells of the latter group were more ‘leaky’ and produced more inflammatory molecules, which allowed more immune cells to penetrate the barrier.

The team observed similar results when the same experiment was conducted in a mouse model of DiGeorge syndrome. Also the researchers performed the same tests in postmortem brain tissue from three people who had DiGeorge syndrome and from three age-matched healthy controls. They observed that the effectiveness of the actual blood-brain barrier of these people had indeed been compromised. The study concludes that schizophrenia and certain other neuropsychiatric conditions may be in part neuroinflammatory disorders.

To Know More You May Refer To:

Crockett, A. M., Ryan, S. K., Vásquez, A. H., Canning, C., Kanyuch, N., Kebir, H., Ceja, G., Gesualdi, J., Zackai, E., McDonald-McGinn, D., Viaene, A., Kapoor, R., Benallegue, N., Gur, R., Anderson, S. A., & Alvarez, J. I. (2021). Disruption of the blood–brain barrier in 22q11.2 deletion syndrome. OUP Academic. https://academic.oup.com/brain/article/144/5/1351/6236329

Up Next

The Secrets Of Waking Up Alert, New Study Reveals

The Secrets Of Waking Up Alert

Health News

Scientists at the University of California, Berkeley, examined tricks to waking up alert and refreshed. The study is published in the journal Nature Communications.

The Study

The researchers made a detailed analysis of the behavior of 833 people who, over a two-week period, were given a variety of sleep, exercise, and breakfast regimes. The participants kept sleep diaries and diet diaries.

The Findings

The results revealed significa


READ FULL ARTICLE ⇲
Up Next

Lucid Dying: Patients Recall Near-Death Experiences During CPR

Lucid Dying

Science News

A research team at NYU Grossman School of Medicine explored the unique phenomenon of CPR-related “lucid dying” experiences. The study was presented in the American Heart Association's Scientific Sessions of 2022.

The Study

The researchers examined 567 men and women from 25 hospitals in the US and the UK, who had CPR and other resuscitation methods used on them after cardiac arrest.

The participants were asked to recall death experiences and recordings of their hidden brain activity were also made. The results were then tallied with the testimonies of 126 community survivors of cardiac arrest with se


READ FULL ARTICLE ⇲
Up Next

Did You Know Breathing Shapes Our Brain And Mental Health?

Breathing Shapes Our Brain And Mental Health

Brain News

A team of researchers at Aarhus University provided insights into how breathing shapes our brains and impacts our mental health. The study is published in the journal Psychological Review.

The Study

The researchers conducted a series of experiments using a combination of human and animal neuroimaging. They also reviewed previously conducted research on the respiration-brain interaction and the calming effect of breathing on the brain.

They examined how the act of breathing exerts a rhythmic influence on neural oscillations, thereby promoting healthy perception, emotional regulation, and cognition.


READ FULL ARTICLE ⇲
Up Next

Long-Term Effects of Childhood Traumas: Study Finds

Long-Term Effects of Childhood Traumas

Mental Health News

A team of researchers at the Desert Research Institute, in the US, explored the long-term health risks of childhood traumas. The study is published in the journal Frontiers in Psychiatry.

The Study

The researchers surveyed more than 16,000 people from the Reno area in Nevada as part of the Healthy Nevada Project. The participants answered questions about their social environments and experiences during their childhood and adolescent years. These included information about emotional, physical, or sexual mistreatment, parental neglect, and substance abuse in the household.

The survey data wa


READ FULL ARTICLE ⇲
Up Next

Research Shows The Power Of Thank You In A Marriage

The Power Of Thank You For Couples

Psychology News

A team of researchers at the University of Illinois, Urbana-Champaign, explored the power of Thank You! in couple relationships. The study is published in the Journal of Social and Personal Relationships.

The Study

In order to understand how does relational gratitude protect couples, the researchers studied 316 middle-aged African American couples in rural Georgia for over 15 months.

The participants completed assessments about conflict resolution, perceived gratitude, expressions of gratitude, financial strain, perceived levels of relationship satisfaction, and perceived levels of relations


READ FULL ARTICLE ⇲
7 Frustrating Things About Living With BPD Black Friday: Is It Triggering Impulsive Buying? The Healing Power Of Music Therapy This Is Not Autism Method Acting And How Its Psychological Toll Runs Deep What You Want To Hear And What You Need To Hear Matthew Perry Opens Up About His Tough Struggle With Addiction What Are The Manipulation Techniques? 5 Honest Parenting Truths For You To Save Do Horror Movies Negatively Impact Our Mental Health? 7 Ways To Overcome Sleeplessness Signs of Depression in Men, Women, and Teens