New Study Identifies The Role Of A Stress Response Gene In Adverse Health Effects

Health News: Scientists explain why exposure to chronic stress early in life shortens lifespan and contributes to age-related chronic diseases and even mental illnesses later in life — long after the source of stress has been removed.

The new study is shedding new light on the gene regulatory pathways activated by cortisol, a stress hormone secreted by the adrenal glands. The research team developed Zebrafish using the CRISPR gene editing technology, in which the genes encoding the glucocorticoid receptor or GR (a transcriptional regulatory protein, responsible for orchestrating gene activity) and its target gene Klf9 were deactivated. Then, scientists compared the stress response in normal fish with those of their genetically altered counterparts.

Results showed that chronic cortisol exposure affects gene activity mainly via the GR, that is activated by cortisol. They have also found that upregulation of proinflammatory gene activity in cortisol-treated zebrafish depends as well on a GR target gene called klf9, another transcriptional regulator.

The associate professor James A. Coffman who led research said, “ Klf9 is a key gene for understanding the optimal regulation of inflammation and how it is compromised by early-life stress.” The study findings build on earlier research in which Coffman showed that chronic exposure to cortisol early in life affects the stress response system that compromises the immune system genes controlling inflammation.

Klf9 seems to play an intriguing role in “inflammaging,” a chronic, low-grade inflammation that is believed to accelerate aging and exacerbate many age-related diseases.

To Know More, You May Refer To:

Gans, I., Hartig, E.I., Zhu, S. et al. Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Sci Rep 10, 11415 (2020). https://doi.org/10.1038/s41598-020-68040-z

Up Next

Can Talking To Strangers Help With Depression?

Can Talking To Strangers Ease Depression

Mental Health News

A group of researchers at the University of Sussex explored how talking to strangers can reduce depression. The study is published in the Journal of Experimental Social Psychology.

The Study

The researchers recruited participants on a weekly basis. The latter played a scavenger hunt game using a mobile app called GooseChase. They then had to talk to a stranger or simply observe the stranger.

After the experiment, they completed “General” and “Daily” surveys. They also answered pre-conversation and post-conversation questionnaires that assesse


READ FULL ARTICLE ⇲
Up Next

Partying With A Purpose: Are There Mental Health Benefits Of Celebrations?

What Are The Mental Health Benefits Of Celebrations

A recent study explored the health benefits of celebrations.

Experts have linked celebrations to reduced risks of mental health conditions.

Why Are Healthy Celebrations Beneficial?

Social celebrations are joyous occasions that essentially include eating, drinking, and gathering together. A recent study conducted by Indiana University revealed that such celebrations are beneficial for health, mental and physical. Its benefits include:

Perceived social support in c

READ FULL ARTICLE ⇲
Up Next

False Memories: Why Do Psychopaths Forget Negative Events?

False Memories

Psychology News

A team of researchers at the University of Bari, Italy, explored the link between psychopathy and the creation of false memories. The study is published in the British Journal of Psychology.

The Study

The researchers asked 120 participants, aged 18–65 years, to complete the Psychopathic Personality Inventory. They assessed the participants’ self-centered impulsivity, fearless dominance, and cold-heartedness.

The latter


READ FULL ARTICLE ⇲
Up Next

Parents’ Political Ideology Impacts How Their Children Punish Others: Study

Parents’ Political Ideology Impacts

Psychology News

A team of researchers at New York University explored how parents’ political ideology dictates their children’s punishment for others. The study is published in the journal Psychological Science.

The Study

The researchers examined 269 children, aged 3−8 years, and their parents from across the United States. They conducted a series of experiments and surveys.

The children were subject to conditions in which they would demonstrate the need to meet out punishment to others within and outside a social group. On the other hand, the parents completed a qu


READ FULL ARTICLE ⇲
Up Next

Research Reveals How Stress Affects Romantic Relationships

How Stress Affects Romantic Relationships

Mental Health News

A team of researchers at the University of Texas, Austin, explored how stress affects romantic relationships. The study is published in the journal Social Psychological and Personality Science.

The Study

The researchers surveyed a daily diary study of 79 newlywed couples. They assessed factors like stressful life events, partner’s negative and positive behaviors, partner perception, etc.

The Findings

The results revealed that


READ FULL ARTICLE ⇲
Billy Milligan: The Man With “24” Faces The Boy Who Stayed Awake For 11 Days Straight How Netflix’s “Wednesday” Explores Adolescent Stress And Therapy What Harry Potter Teaches Us About Mental Health? Nocturnal Panic Attacks: What are they & how to recover 10 Best Healthy Foods To Beat The Holiday Blues What Are The Struggles During Holidays & 5 Ways To Prevent It Holiday Depression: 13 Tips To Beat Holiday Blues I am feeling so “behind” in life 7 Frustrating Things About Living With BPD Are You An Impulse Shopper? 9 Tips To Stop Impulse Buying The Healing Power Of Music Therapy