A team of researchers at King’s College London invented a new test to detect Alzheimer’s disease. The study is published in the journal Brain.
The researchers collected and surveyed blood samples, for over several years, from 56 individuals with Mild Cognitive Impairment (MCI). MCI is a health condition in which a person begins to experience a worsening of his/her memory or cognitive ability. They developed a blood-based test for the experiment.
The results revealed that the new blood-based test can help detect the risk of Alzheimer’s disease for up to 3.5 years before clinical diagnosis. It can help stratify individuals undergoing neurodegeneration or loss of brain cells in the early stages of memory disorders like Alzheimer’s disease.
The authors added: “Our findings are extremely important, potentially allowing us to predict the onset of Alzheimer’s early in a non-invasive fashion. This could complement other blood-based biomarkers that reflect the classical signs of the disease.”
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Maruszak, A., Silajdžić, E., Lee, H., Murphy, T., Liu, B., Shi, L., de Lucia, C., Douiri, A., Salta, E., Nevado, A. J., Teunissen, C. E., Visser, P. J., Price, J., Zetterberg, H., Lovestone, S., & Thuret, S. (2023). Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serum. Brain : a journal of neurology, awac472. Advance online publication. https://doi.org/10.1093/brain/awac472