Mania

Mania is a disabling psychiatric disorder that affects a person’s physical health and mental wellbeing. Mania is often associated with bipolar disorders, schizoaffective disorders, and psychosis.

What Is Mania?

Mania is a mental and behavioral disorder characterized by altered energy levels, moods, and patterns. The word is derived from Ancient Greek “μανία” (manía) meaning frenzy. A person afflicted with mania experiences overactive and aggressive behavior, thought and speech disturbances, unrealistic expansiveness of mood, and vegetative symptoms. Moreover, several disorders accompany manic syndrome, such as bipolar disorders, schizoaffective disorders, anxiety, psychosis, dementia, depression, obsessive-compulsive disorders, and impulse-control disorders.

Experiencing uncontrolled psychomotor acceleration, the person engages in goal-oriented activities with negative consequences and this causes major deficits in his/her social and occupational functioning. This consequently harms relationships, reputations, and careers. Other consequential complications include engagement in violence and substance abuse, harboring of suicidal instincts, and causing harm to self and other.

Mania should be distinguished from “heightened states” induced by substance abuse or medications. It should be considered in its entirety a multi-dimensional “natural state” associated with bipolar disorders, schizoaffective disorders, or other medical disorders. Research [mfn] Mania. (2021). The Recovery Village Drug and Alcohol Rehab. https://www.therecoveryvillage.com/mental-health/mania/ [/mfn] shows that it is a common mental disorder, with 0.4–1.6% of adults experiencing an episode of mania at some point in their lives.

Prevalence Of Mania

Mania, with bipolar and schizoaffective disorders, are diagnostic criteria for each other and this can aid in gauging the prevalence of mania. Both men and women are equally affected by mania, the median age of onset of the disorder being age 25. Men typically experience an earlier onset, whereas women are susceptible to severe mood disorder episodes in a given year.

Most research reports that, statistically, 0.4–1.6% of adults will have an episode of mania at some point in their lives. There is some more recent research that reports this rate may be as high as 5–7%. Data concerning mania, however, are frequently inadequate, especially in developing and underdeveloped countries, owing to social taboo surrounding mental health, dearth of information about and unawareness of mental disorders, and lack of medical infrastructure.

Types Of Mania

Most of the time, Mania is a key-component in medical conditions and psychiatric disorders–because of which, it is a multi-dimensional syndrome and varies in intensity. It ranges through mild, moderate, and severe and is divided into three stages:

• Hypomania (Stage I): Hypomania is the mildest form of mania, a stage characterized by decreased sleep, irritability, and euphoria. It is popularly associated with increased productivity and creativity. However, if untreated, it can lead to severe mania and death.
• Acute Mania (Stage II): Acute mania is the second stage towards a manic episode, characterized by lack of sleep, rash actions, lack of judgment, and, in some cases, the onset of psychosis.
• Delirious Mania (Stage III): Delirious mania is the most severe of the three stages of mania and requires hospitalization. A person at this stage descends into a manic episode and experiences delirium and psychosis.

Mania can also manifest itself in mixed affective states [mfn] Regier, D. A., Kuhl, E. A., & Kupfer, D. J. (2013). The DSM-5: Classification and criteria changes. World psychiatry : official journal of the World Psychiatric Association (WPA), 12(2), 92–98. https://doi.org/10.1002/wps.20050 [/mfn] . According to the American Psychiatric Association’s DSM-5, a person is taken to be experiencing a “manic episode” when she/he experiences, for a period of time (spanning 4 days to 1 week), three or more concurrent symptoms of mania (catatonia, disorientation, incoherence, and florid psychosis) and associated mental disorders like depression [mfn] Fuchs, T. (2014). Psychopathology of depression and mania: Symptoms, phenomena and syndromes. ResearchGate. https://www.researchgate.net/publication/275147435_Psychopathology_of_depression_and_mania_Symptoms_phenomena_and_syndromes [/mfn] , cyclothymia [mfn] Bielecki JE, Gupta V. Cyclothymic Disorder. [Updated 2021 Jul 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557877/ [/mfn], bipolar disorders [mfn] Baldessarini, R. J., Vieta, E., Calabrese, J. R., Tohen, M., & Bowden, C. L. (2010). Bipolar depression: Overview and commentary. Harvard Review of Psychiatry, 18(3), 143-157. https://doi.org/10.3109/10673221003747955 [/mfn] , schizoaffective disorders, etc.

Read More About Hypomania Here

Causes Of Mania

The etiology of mania is not known and its cause is attributed to a plethora of genetic, psychological, and social factors.

1. Genetic Factors

Mania can be transmitted through genetic constitution. For instance, multiple family studies [mfn] Dailey MW, Saadabadi A. Mania. [Updated 2021 Aug 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493168/ [/mfn] involving monozygotic twins have confirmed the genetic factor in monomania, citing that almost 80% of twins are concordant for mania when/if one of the siblings are positive for the disorder. Other studies show that several allele frequencies are involved in mania.

2. Physiological Factors

The pathophysiology [mfn] Martino, D. J., Valerio, M. P., & Parker, G. (2020). The structure of mania: An overview of factorial analysis studies. European psychiatry : the journal of the Association of European Psychiatrists, 63(1), e10. https://doi.org/10.1192/j.eurpsy.2020.18 [/mfn] of mania and the associated bipolar disorders and schizoaffective disorders reveal that the neurocognitive profile of mania is highly consistent with dysfunction in the right prefrontal cortex and right hemisphere lesions. Disorders in thalamic activity and behavioral activation system activity, a failure of serotonergic regulation, and dopaminergic hyperactivity point to triggering manic episodes. Mania is also caused by abnormalities in GSK-3, Protein kinase C, and Inositol monophosphatase. It is also associated with medical conditions and neurological conditions like stroke, Parkinson’s disease [mfn] Canesi, M., Lavolpe, S., Cereda, V., Ranghetti, A., Maestri, R., Pezzoli, G., & Rusconi, M. L. (2020). Hypomania, depression, Euthymia: New evidence in Parkinson’s disease. Behavioural Neurology, 2020, 1-8. https://doi.org/10.1155/2020/5139237 [/mfn] , lupus, and brain injury as well as triggers like antidepressant therapy and medications that use glutaminergic agents.

3. Social Factors

Anecdotal evidence further points to psychosocial factors that trigger manic phases, such as physical trauma, prolonged illness, or stressful life events (involving grief, childbirth, seasonal changes [mfn] Bostock, E. C., Kirkby, K. C., Garry, M. I., & Taylor, B. V. (2015). Comparison of precipitating factors for mania and partial seizures: Indicative of shared pathophysiology? Journal of Affective Disorders, 183, 57-67. https://doi.org/10.1016/j.jad.2015.04.057 [/mfn] ). Lifestyle choices like sleep deprivation, recreational drug and alcohol abuse, and irregular schedules also cause mania. It is also associated with personality disorders, which are themselves products of environmental dictates of the afflicted.

Symptoms Of Mania

In the original study [mfn] Mondimore, F. M. (2005). Kraepelin and manic-depressive insanity: An historical perspective. International Review of Psychiatry, 17(1), 49-52. https://doi.org/10.1080/09540260500080534 [/mfn] of manic-depressive insanity, Emil Kraepelin inferred the fundamental clinical triad for the recognition of the disorder, namely, euphoria, pressured speech, and hyperactivity. Western psychiatry stuck to these historical diagnostic criteria until the publication of the Feighner Criteria, the Research Diagnostic Criteria (RDC), and the Diagnostic and Statistical Manuals of Mental Disorders (including DSM-III and successive DSM editions) in the later half of the 20th century. These studies emphasized mood abnormalities, along with the other symptoms. A 2020 study [mfn] Martino, D. J., Valerio, M. P., & Parker, G. (2020). The structure of mania: An overview of factorial analysis studies. European psychiatry : the journal of the Association of European Psychiatrists, 63(1), e10. https://doi.org/10.1192/j.eurpsy.2020.18 [/mfn] lists 37 clinical variables for mania. However, mania has a subset of homogenous symptoms:

• Hyper-activity
• Elevated mood
• Increased speech
• Irritability
• Grandiosity
• Psychosis
• Distractibility
• Sleep and thought disorders
• Poor judgment

The common mnemonic “DIG FAST” [Distractibility, Irresponsibility or Irritability, Grandiosity, Flight of ideas, increased Activity, decreased Sleep, and excessive Talkativeness] is employed by clinicians to enquire into suspected mania. Sometimes, increased sexuality and sociability are also associated with mania. Nonetheless, the varied nature of mania means that the psychiatric verdict on its key constructs is derived more from expert consensus than empirical data.

Read More About Psychosis Here

Diagnosis Of Mania

When a patient presents with mania, an exhaustive evaluation is carried out to rule out other differentials. The basic laboratory values needed in assessing a manic patient include:

• Physical examination to determine BMI calculation, blood pressure, and an EKG.
• Neurological examination to screen for possible dementia and other mental disorders
• Medication list review
• Assessment of mood, state and severity
• Baseline lab tests to determine complete metabolic panel (CMP), thyroid panel, blood count (CBC), urine toxicology screen, lipid panel, HIV, etc.
• Neuroimaging
• Brain imaging tests, such as CT or MRI scans, particularly in people under the age of 13 or over the age of 60

While “DIG FAST” is used to understand the basic symptoms of mania, scientific tools and mania-rating instruments such as Altman Self-Rating Mania Scale and Young Mania Rating Scale [mfn] Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978). Young mania rating scale. PsycTESTS Dataset. https://doi.org/10.1037/t20936-000 [/mfn] can be used to measure severity of manic episodes.

Treatment Of Mania

Mania, much like other mental health disorders, can be treated in a number of ways:

1. Medication

Following thorough differential diagnoses [mfn] Loro, B., & Woodward, J. A. (1975). The dependence of psychiatric diagnosis on psychological assessment. Journal of clinical psychology, 31(4), 635–639. https://doi.org/10.1002/1097-4679(197510)31:4<635::aid-jclp2270310411>3.0.co;2-j [/mfn], mania is treated with atypical antipsychotic medication [mfn] Butler M, Urosevic S, Desai P, et al. Treatment for Bipolar Disorder in Adults: A Systematic Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Aug. (Comparative Effectiveness Review, No. 208.) Appendix G, Other Drugs for Acute Mania. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532186/ [/mfn] (consumption of haloperidol, risperidone, olanzapine, quetiapine, aripiprazole) or the utilization of mood stabilizers (consumption of carbamazepine, valproate, lithium, or lamotrigine) and anticonvulsants.

The use of medication [mfn] Vieta, E., & Sanchez-Moreno, J. (2008). Acute and long-term treatment of mania. Dialogues in clinical neuroscience, 10(2), 165–179. https://doi.org/10.31887/DCNS.2008.10.2/evieta [/mfn] is influenced by a number of factors: the patient’s current and prior medication history; the need for rapid resolution of agitation and aggression; the characteristics of the manic episode; the presence of rapid cycling; the patient’s own willingness to accept particular therapies and routes of administration. Medication aids functional recovery in the long-term if taken punctually and with therapy.

2. Therapy

Manic patients can seek psychiatric help in therapy that explores faulty cognitions and psychological distress and seeks to address the “integration of service users’ thoughts, feelings and behaviors that are contributing to the presenting problem”. Manic patients can avail counseling sessions, psychotherapy [mfn] Cook, S. C., Schwartz, A. C., & Kaslow, N. J. (2017). Evidence-Based Psychotherapy: Advantages and Challenges. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 14(3), 537–545. https://doi.org/10.1007/s13311-017-0549-4 [/mfn], cognitive behavioral therapy (CBT) [mfn] (PDF) Cognitive behavioural therapy. (2013). ResearchGate. https://www.researchgate.net/publication/264932879_Cognitive_Behavioural_Therapy [/mfn] , or other forms of therapy that encourage patients to develop self-help coping strategies and healthy lifestyle choices. In some cases, long-term prophylactic treatment (combining pharmacotherapy and psychotherapy) is used to treat mania. In clinical practice, cases of mania employ combination therapy for functional recovery in the long-term.

Read More About Therapy Here

3. Community Help

Psychoeducation, social support, and support groups are long-term combatants of any psychological disorder (including mania) for patients, their families, and caregivers.

4. Hospitalization and Emergency Help

Severe manic episodes call for hospitalization and management of violent and aggressive maniac patients in well-equipped medical facilities by an efficient interprofessional team consisting of a psychiatrist, a psychologist, a mental health nurse, a primary care provider, and a social worker. In rare cases, electroconvulsive therapy (ECT) [mfn] Anand S. (2016). Ultrabrief Electroconvulsive Therapy for Manic Episodes of Bipolar Disorder. The journal of ECT, 32(4), 267–269. https://doi.org/10.1097/YCT.0000000000000323 [/mfn] is administered to people experiencing life-threatening manic episodes.

Living With Mania

A person afflicted with mania experiences overactive and aggressive behavior, thought and speech disturbances, unrealistic expansiveness of mood, and vegetative symptoms. Moreover, several disorders accompany manic syndrome, such as bipolar disorders, schizoaffective disorders, anxiety, psychosis, dementia, depression, obsessive-compulsive disorders, and impulse-control disorders.

Experiencing uncontrolled psychomotor acceleration, the person engages in goal-oriented activities with negative consequences and this causes major deficits in his/her social and occupational functioning. This consequently harms relationships, reputations, and careers. Other consequential complications include engagement in violence and substance abuse, harboring of suicidal instincts, and causing harm to self and other.

A person suffering from mania (and its related disorders) is advised to:

• Seek psychiatric help
• Learn about the treatment and adhere to therapy and medication
• Keep track of the treatment process, identify the particulars and onset of a manic episode, and monitor signs of relapses
• Keep at ready the emergency helpline to ask for help when needed
• Maintain a healthy lifestyle, with a balanced diet and proper sleep schedule
• Spend time with loved ones
• Practice self-care activities [mfn] Knight E. L. (2006). Self-help and serious mental illness. MedGenMed : Medscape general medicine, 8(1), 68. [/mfn] that brings happiness and positivity

Read More About Bipolar Disorder Here

Prognosis Of Mania

Like most other psychiatric disorders, mania can be managed if treated timely and patients are punctual adherents of therapy and medications. Convalescence is uncertain and guarded, given that recuperation is sometimes vulnerable to volatile relapses into violence, substance abuse, depression, and/or even suicide. Recovery from mania is also influenced by factors such as a history of abuse, low socioeconomic status, inability to afford expensive mental healthcare facilities, comorbidities, the longevity of mental illness and suffering, or sudden triggering events. Nonetheless, recovery is possible.

Mania At A Glance

1. Mania is a common mental disorder that can be diagnosed and managed with proper therapy and medication.
2. Mania is often accompanied by other disorders, such as bipolar disorders, schizoaffective disorders, anxiety, psychosis, dementia, depression, obsessive-compulsive disorders, and impulse-control disorders.
3. The symptoms of mania comprise catatonia, disorientation, incoherence, and florid psychosis.
4. Mania impacts the patient’s social and occupational functioning, harming relationships, reputations, and careers.
5. If untreated, manic episodes can become violent and suicidal.